Peer-reviewed Publications
Steady-state kinetic modeling | PMID: 19266013  
Purvis JE, Radhakrishnan R, Diamond SL. Steady-state kinetic modeling constrains cellular resting states and dynamic behavior. (2009) PLoS Comput Biol. 5(3):e1000298.  
Molecular systems biology of ErbB1 signaling  | PMID: 19396377  
Shih AJ, Purvis J, Radhakrishnan R. Molecular systems biology of ErbB1 signaling: bridging the gap through multiscale modeling and high-performance computing. (2008) Mol Biosyst. 4(12):1151-9.  
Molecular docking of Cathepsin L inhibitors | PMID: 18598021  
Beavers MP, Myers MC, Shah PP, Purvis JE, Diamond SL, Cooperman BS, Huryn DM, Smith AB 3rd. Molecular Docking of Cathepsin L Inhibitors in the Binding Site of Papain. (2008) J Chem Inf Model. 48(7):1464-72.  
Computational human platelet model | PMID: 18596227  
Purvis JE, Chatterjee MS, Brass LF, Diamond SL. A molecular signaling model of platelet phosphoinositide and calcium regulation during homeostasis and P2Y1 activation. (2008) Blood. 112(10):4069-79.  
Network branching model for EGFR | PMID: 18412405  
Purvis, J, Ilango, V, Radhakrishnan, R. Role of Network Branching in Eliciting Differential Short-Term Signaling Responses in the Hyper-Sensitive Epidermal Growth Factor Receptor Mutants Implicated in Lung Cancer. (2008) Biotechnol Prog. 24(3):540-53.  
A potent Cathepsin L inhibitor | PMID: 18403718  
Shah PP, Myers MC, Beavers MP, Purvis JE, Jing H, Grieser HJ, Sharlow ER, Napper AD, Huryn DM, Cooperman BS, Smith AB, Diamond SL. Kinetic Characterization and Molecular Docking of a Novel, Potent, and Selective Slow-binding Inhibitor of Human Cathepsin L. (2008) Mol Pharmacol. 74(1):34-41.  
Inhibition model for EGFR signaling    
Purvis J, Liu Y, Ilango V, Radhakrishnan R. Efficacy of tyrosine kinase inhibitors in the mutants of the epidermal growth factor receptor through a multiscale molecular/ systems model for phosphorylation and inhibition. (2007) Proceedings of Foundations of Systems Biology in Engineering.  
Multiscale signaling model for EGFR | PMID: 17273938    
Liu Y, Purvis J, Shih A, Weinstein J, Agrawal N, Radhakrishnan R. A multiscale computational approach to dissect early events in the Erb family receptor mediated activation, differential signaling, and relevance to oncogenic transformations. (2007) Ann Biomed Eng. 35(6):1012-25.  
Engineering osmotolerance in E. coli | PMID: 16000787    
Purvis JE, Yomano LP, Ingram LO. Enhanced trehalose production improves growth of Escherichia coli under osmotic stress. Appl Environ Microbiol. (2005) 71:3761-9.  
Microarray analysis of ethanol tolerance | PMID: 12675606    
Gonzalez R, Tao H, Purvis JE, York SW, Shanmugam KT, Ingram LO. Gene array-based identification of changes that contribute to ethanol tolerance in ethanologenic Escherichia coli: comparison of KO11 (parent) to LY01 (resistant mutant). Biotechnol Prog. 2003 19:612-23.