Jeremy is the sole member
of the Purvis Lab. Born in Sarasota, Florida in 1979, he received
a B.S. (2002) and M.S. (2004) in Microbiology from the University
of Florida under the supervision of Lonnie
Ingram. In a bold display of adventure, Jeremy left the
golden shores of Florida to pursue a degree in Genomics
and Computational Biology at the University
of Pennsylvania in Philadelphia. Mentored by Scott Diamond
(Chemical Engineering) and Ravi Radhakrishnan (Bioengineering),
his doctoral work has focused on understanding cellular signaling
from a systems perspective.
This piece was written for the Literature Review and
Analysis portion of the 2007 Genomics and Computational
Biology preliminary exam 2007. Penn has an especially high
concentration of genome-wide association expertise and the
focus of this analysis was the variability in gene expression
— itself a heritable trait
detectable by genetical genomics.
Written as
a assignment for an independent study (Statistical
Methods in Bioinformatics), this piece was intended
mostly to humor our illustrious statistician and friend,
Warren Ewens.
A student of the frequentist old school, Warren was
always suspicious of Bayesian analysis and once interrupted class to
confront us each about our opinion of the Bayesian approach.
Despite the biting tone of the critique, I am actually quite
fond of the
Sachs
article as it has greatly influenced my thinking.
Also a class
assignment (Principles
in Computational Biology), this paper examines a
recent collection of machine learning techniques and focuses on the generalizability of each method.