C0 S0001 S0002 S0003 S0034 C1 S0004 S0005 S0006 S0009 S0015 S0017 2 S0018 2 S0019 2 S0020 2 S0021 S0026 S0027 S0028 S0029 S0033 S0040 S0041 S0042 2 S0043 2 S0044 2 S0045 2 S0046 2 S0047 3 S0055 3 S0056 2 S0057 2 S0058 2 S0059 2 S0060 4 S0061 3 S0062 3 S0063 2 S0064 2 S0065 3 S0066 3 S0074 3 S0075 2 S0076 3 S0077 2 S0078 3 S0079 3 S0080 4 S0082 3 S0083 3 S0085 3 S0086 2 S0087 4 S0090 5 S0091 3 S0092 S0093 5 S0094 5 S0095 6 S0096 3 S0097 2 S0098 5 S0099 S0101 6 S0102 6 S0103 2 S0104 2 S0105 2 S0106 C2 S0007 S0008 S0010 S0011 S0012 S0013 S0014 S0016 S0022 S0023 S0024 S0025 S0030 S0031 S0032 S0035 S0037 2 S0048 2 S0049 S0050 2 S0067 S0068 S0069 2 S0070 S0081 2 S0088 2 S0089 S0100 S0107 C3 S0038 S0039 2 S0051 2 S0052 3 S0053 3 S0054 3 S0071 2 S0072 3 S0073 4 S0084 C4 S0036 S0001 S0043 S0057 S0062 S0075 S0079 S0085 S0002 S0044 S0059 S0063 S0077 S0080 S0086 S0003 S0045 2 S0061 2 S0082 S0087 2 S0090 2 S0091 S0092 2 S0094 2 S0095 2 S0096 S0097 2 S0099 2 S0102 2 S0103 S0005 S0042 S0044 S0047 S0059 S0060 S0063 S0065 S0077 S0078 S0080 S0086 S0004 S0041 S0043 S0046 S0057 S0058 S0062 S0064 S0075 S0076 S0079 S0085 S0006 S0045 2 S0061 2 S0082 S0087 2 S0090 2 S0091 S0092 S0093 2 S0094 2 S0095 2 S0096 S0097 S0098 2 S0099 2 S0102 2 S0103 S0104 S0007 S0046 S0047 S0048 S0058 S0060 S0062 S0063 S0064 S0065 S0070 S0075 S0076 S0077 S0078 S0079 S0080 S0081 S0085 S0086 S0088 S0089 S0008 S0091 S0092 S0094 S0095 2 S0096 S0097 S0098 S0099 S0100 2 S0102 2 S0103 S0104 S0009 S0101 S0105 S0106 S0010 S0048 S0069 S0070 S0088 S0089 S0011 S0105 S0106 S0107 S0022 S0052 S0071 S0072 S0084 S0025 S0068 S0037 S0049 S0050 S0066 S0067 S0083 S0038 S0051 S0052 S0071 S0072 S0084 S0052 S0071 S0040 S0055 S0056 S0074 S0039 S0053 S0054 S0073 0.24996 S0039 0.74989 S0039 0.00014998 S0039 0.24996 S0040 0.74989 S0040 0.00014998 S0040 IP3R_o IP3R_tot IP3R_a IP3R_tot 0.9 p_IP3R_a 0.1 p_IP3R_o 0.9 p_IP3R_a 0.1 p_IP3R_o 0.9 p_IP3R_a 0.1 p_IP3R_o 0.9 p_IP3R_a 0.1 p_IP3R_o P_o IP3R_tot 4 1.348 -2 S0036 S0035 1.348 -2 S0034 S0035 S0038 k_IP3R_k1 k_IP3R_L1 k_IP3R_l2 S0035 k_IP3R_L1 S0035 1 k_IP3R_L1 k_IP3R_L3 S0051 k_IP3R_k1b k_IP3R_l2b S0038 S0022 k_IP3R_k2 k_IP3R_L3 k_IP3R_l4 S0035 k_IP3R_L3 S0035 1 k_IP3R_L3 k_IP3R_L1 S0052 k_IP3R_k2b k_IP3R_l4b S0035 1 S0035 k_IP3R_L5 S0052 k_IP3R_k4 k_IP3R_L5 k_IP3R_l6 S0035 k_IP3R_L5 S0035 S0071 k_IP3R_L1 k_IP3R_k4b k_IP3R_l6b k_IP3R_L1 S0035 S0071 k_IP3R_k1 k_IP3R_L1 k_IP3R_l2 S0035 k_IP3R_L1 S0035 S0051 k_IP3R_k1b k_IP3R_l2b S0052 k_IP3R_k3 k_IP3R_L5 k_IP3R_L5 S0035 S0072 k_IP3R_k3b C1 kact S0004 C1 kact S0005 C0 kon S0001 C1 C0 S0004 C0 kon S0002 C1 C0 S0005 C0 kon S0003 C1 C0 S0006 C1 kon S0004 C2 C1 S0007 C1 kon S0005 C2 C1 S0007 C2 kon S0007 S0010 C2 Km_PLCg S0011 C1 C2 S0021 kcat_PLCg S0011 C2 Km_PLCg S0011 C1 C2 S0020 kcat_PLCg S0011 C2 Km_PLCg S0011 C1 C2 S0019 kcat_PLCg S0011 C1 kcat_PI4K S0019 S0027 Km_PI4K S0019 C1 kcat_PIP5K S0020 S0028 Km_PIP5K S0020 C1 kcat_PIP2P S0021 S0029 Km_PIP2P S0021 C2 kcat_IPP S0024 S0030 Km_IPP S0024 C2 kcat_IP2P S0023 S0031 Km_IP2P S0023 C1 kcat_DAGK S0015 C2 C1 S0032 Km_DAGK S0015 C2 kcat_CDPDAGS S0014 C1 C2 S0017 C1 C2 S0033 Km_CDPDAGS_CTP S0014 Km_CDPDAGS_PA C1 C2 S0017 C2 kcat_PIS S0016 C1 C2 S0018 C1 C2 S0026 Km_PIS_Ins S0016 Km_PIS_CDPDAG C1 C2 S0018 C2 kcat_IP3P S0022 S0025 Km_IP3P S0022 C2 kon_PKC_Ca S0035 S0037 C2 kf_Activation_of_PKC S0037 C2 v01_IP3R S0035 C3 C2 S0038 C2 v03_IP3R S0022 C3 C2 S0038 C2 k_SERCA_2f S0035 S0035 C3 C2 S0039 C4 k_SERCA_5f S0036 S0036 C3 C4 S0039 C2 k_PMCA_2f S0035 S0035 C1 C2 S0040 C0 k_PMCA_5f S0034 S0034 C1 C0 S0040 C1 kact S0043 C1 kact S0046 C1 k_inact_P2Y1a S0041 C1 kact S0044 C1 kact S0047 C1 k_inact_PAR1a S0042 C1 0.5 kon S0045 S0045 C0 kon S0001 C1 C0 S0041 C0 kon S0001 C1 C0 S0046 C1 koff_ADP_P2Y1 S0043 C0 kon S0002 C1 C0 S0042 C0 kon S0002 C1 C0 S0047 C1 koff_TRAP_PAR1 S0044 C1 koff_CVX_GPVI S0045 C2 kon S0007 C1 C2 S0043 C2 kon S0007 C1 C2 S0041 C1 koff_R_GqGDP S0046 C2 kon S0007 C1 C2 S0044 C2 kon S0007 C1 C2 S0042 C1 koff_R_GqGDP S0047 C1 k_exch S0046 C1 k_exch S0047 C2 koff_PLCb_GqGDP S0048 C2 koff_PKC_Ca S0049 C1 kon_PKC_Ca_DAG S0015 C2 C1 S0049 C2 kb_Activation_of_PKC S0050 C2 kf_Activation_of_PKC_Ca S0049 C2 kcat_PKC S0025 S0050 Km_PKC S0025 C2 kcat_PKC S0010 S0050 Km_PKC S0010 C2 kcat_PKC S0048 S0050 Km_PKC S0048 C3 v02_IP3R S0051 C3 v04_IP3R S0052 C2 v05_IP3R S0035 C3 C2 S0052 C3 v09_IP3R S0052 C3 k_SERCA_2r S0053 C3 k_SERCA_3f S0053 C3 k_SERCA_4r S0054 C3 k_SERCA_5r S0054 C1 k_PMCA_2r S0055 C1 k_PMCA_3f S0055 C1 k_PMCA_4r S0056 C1 k_PMCA_5r S0056 C1 kact S0062 C1 kact S0064 C1 k_inact_P2Y1a S0057 C1 k_inact_P2Y1a S0058 C1 kact S0063 C1 kact S0065 C1 k_inact_PAR1a S0059 C1 k_inact_PAR1a S0060 C1 koff_GPVI_GPVI S0061 C0 kon S0001 C1 C0 S0058 C0 kon S0001 C1 C0 S0064 C1 koff_ADP_P2Y1 S0057 C1 koff_ADP_P2Y1 S0062 C0 kon S0002 C1 C0 S0060 C0 kon S0002 C1 C0 S0065 C1 koff_TRAP_PAR1 S0059 C1 koff_TRAP_PAR1 S0063 C2 kon S0007 C1 C2 S0057 C1 koff_RL_GqGDP S0062 C1 koff_R_GqGDP S0058 C2 kon S0007 C1 C2 S0059 C1 koff_RL_GqGDP S0063 C1 koff_R_GqGDP S0060 C1 koff_R_GqGTP S0064 C1 koff_R_GqGTP S0065 C1 k_exch S0058 C1 k_exch S0060 C1 k_exch S0062 C1 k_exch S0063 C1 k_hydrol S0064 C1 k_hydrol S0065 C2 kon S0007 S0069 C2 koff_PLCb_GqGDP S0070 C2 2 kcat_TK S0012 C1 C2 S0061 Km_TK S0012 C2 kcat_Pase S0013 S0069 Km_Pase S0013 C2 kcat_Pase S0013 S0070 Km_Pase S0013 C2 kcat_Pase S0013 S0068 Km_Pase S0013 C2 kcat_pIP3P S0022 S0068 Km_IP3P S0022 C1 koff_PKC_Ca_DAG S0066 C2 kb_Activation_of_PKC_Ca S0067 C1 kf_Activation_of_PKC_Ca_DAG S0066 C2 kcat_PKC S0025 S0067 Km_PKC S0025 C3 v06_IP3R S0071 C2 v07_IP3R S0035 C3 C2 S0071 C3 v10_IP3R S0072 C3 k_SERCA_3r S0073 C3 k_SERCA_4f S0073 C1 k_PMCA_3r S0074 C1 k_PMCA_4f S0074 C1 kact S0079 C1 k_inact_P2Y1a S0075 C1 k_inact_P2Y1a S0076 C1 kact S0080 C1 k_inact_PAR1a S0077 C1 k_inact_PAR1a S0078 C1 koff_GPVI_GPVI S0082 C0 kon S0001 C1 C0 S0076 C1 koff_ADP_P2Y1 S0075 C1 koff_ADP_P2Y1 S0079 C0 kon S0002 C1 C0 S0078 C1 koff_TRAP_PAR1 S0077 C1 koff_TRAP_PAR1 S0080 C1 koff_RL_GqGDP S0075 C1 koff_RL_GqGDP S0077 C1 kon S0043 C2 C1 S0081 C1 kon S0057 C2 C1 S0081 C1 koff_RL_GqGTP S0079 C1 kon S0004 C2 C1 S0081 C1 kon S0041 C2 C1 S0081 C1 koff_R_GqGTP S0076 C1 kon S0044 C2 C1 S0081 C1 kon S0059 C2 C1 S0081 C1 koff_RL_GqGTP S0080 C1 kon S0005 C2 C1 S0081 C1 kon S0042 C2 C1 S0081 C1 koff_R_GqGTP S0078 C1 k_exch S0075 C1 k_exch S0077 C1 k_hydrol S0076 C1 k_hydrol S0078 C1 k_hydrol S0079 C1 k_hydrol S0080 C2 k_hydrol S0081 C2 kon S0010 S0081 C2 kon S0069 S0081 C1 koff_GPVI_GPVI S0082 C2 kcat_TK S0012 C1 C2 S0082 Km_TK S0012 C2 kon S0008 C1 C2 S0082 C2 kcat_Pase S0013 C1 C2 S0082 Km_Pase S0013 C1 kb_Activation_of_PKC_Ca_DAG S0083 C2 kcat_PKC S0025 C1 C2 S0083 Km_PKC S0025 C3 v08_IP3R S0084 C1 k_inact_P2Y1a S0085 C1 k_inact_PAR1a S0086 C1 kon S0045 S0087 C1 0.5 kon S0087 S0087 C1 koff_GPVI_GPVI S0090 C1 koff_GPVI_GPVI S0091 C1 koff_ADP_P2Y1 S0085 C1 koff_TRAP_PAR1 S0086 C1 koff_CVX_GPVI S0087 C1 koff_RL_GqGTP S0085 C1 koff_RL_GqGTP S0086 C1 k_hydrol S0085 C1 k_hydrol S0086 C2 k_hydrol S0088 C2 k_hydrol S0089 C2 koff_PLCb_GqGTP S0088 C2 koff_PLCb_GqGTP S0089 C2 kcat_PLCb_GqGTP S0088 C2 kcat_PLCb_GqGTP S0089 C1 kon S0045 S0087 C1 koff_GPVI_GPVI S0091 C2 kcat_TK S0012 C1 C2 S0091 Km_TK S0012 C2 kon S0008 C1 C2 S0087 C2 2 kon S0008 C1 C2 S0090 C1 koff_SH2 S0091 C2 kcat_TK S0012 C1 C2 S0091 Km_TK S0012 C2 kcat_Pase S0013 C1 C2 S0087 Km_Pase S0013 C2 2 kcat_Pase S0013 C1 C2 S0090 Km_Pase S0013 C2 kcat_Pase S0013 S0089 Km_Pase S0013 C1 kcat_PLCb_PIP2 S0021 C2 C1 S0088 Km_PLCb_PIP2 S0021 C1 kcat_PLCb_PIP2 S0021 C2 C1 S0089 Km_PLCb_PIP2 S0021 C1 kcat_PLCb_PIP S0020 C2 C1 S0088 Km_PLCb_PIP S0020 C1 kcat_PLCb_PIP S0020 C2 C1 S0089 Km_PLCb_PIP S0020 C1 kcat_PLCb_PI S0019 C2 C1 S0088 Km_PLCb_PI S0019 C1 kcat_PLCb_PI S0019 C2 C1 S0089 Km_PLCb_PI S0019 C2 kcat_PKC S0050 S0088 Km_PKC S0050 C1 kon S0045 S0092 C1 kon S0087 S0092 C1 0.5 kon S0092 S0092 C1 koff_GPVI_GPVI S0094 C1 koff_GPVI_GPVI S0095 C0 kon S0003 C1 C0 S0093 C1 koff_CVX_GPVI S0092 C1 kon S0045 S0092 C1 kon S0087 S0092 C1 koff_GPVI_GPVI S0094 C1 koff_GPVI_GPVI S0095 C2 kcat_TK S0012 C1 C2 S0095 Km_TK S0012 C2 kon S0008 C1 C2 S0093 C2 kon S0008 C1 C2 S0094 C1 koff_SH2 S0092 C1 koff_SH2 S0094 C1 koff_SH2 S0095 C2 kcat_TK S0012 C1 C2 S0092 Km_TK S0012 C2 kcat_TK S0012 C1 C2 S0094 Km_TK S0012 C1 kcat_TK S0009 S0095 Km_TK S0009 C2 kcat_Pase S0013 C1 C2 S0093 Km_Pase S0013 C2 kcat_Pase S0013 C1 C2 S0094 Km_Pase S0013 C2 kcat_Pase S0013 C1 C2 S0095 Km_Pase S0013 C1 kon S0045 S0097 C1 kon S0087 S0097 C1 kon S0092 S0097 C1 0.5 kon S0097 S0097 C1 koff_GPVI_GPVI S0096 C1 koff_GPVI_GPVI S0099 C0 kon S0003 C1 C0 S0098 C1 koff_CVX_GPVI S0097 C1 kon S0045 S0097 C1 kon S0087 S0097 C1 kon S0092 S0097 C1 koff_GPVI_GPVI S0099 C1 kon S0082 C2 C1 S0100 C1 kon S0087 C2 C1 S0100 C1 2 kon S0090 C2 C1 S0100 C1 kon S0093 C2 C1 S0100 C1 kon S0094 C2 C1 S0100 C2 kon S0008 C1 C2 S0099 C1 kon S0099 C2 C1 S0100 C1 2 koff_SH2 S0096 C1 koff_SH2 S0097 C1 koff_SH2 S0098 C1 koff_SH2 S0099 C2 2 kcat_TK S0012 C1 C2 S0096 Km_TK S0012 C2 kcat_TK S0012 C1 C2 S0098 Km_TK S0012 C1 kcat_TK S0009 S0097 Km_TK S0009 C1 kcat_TK S0009 S0099 Km_TK S0009 C2 kon S0011 C1 C2 S0101 C2 kcat_Pase S0013 C1 C2 S0099 Km_Pase S0013 C2 kcat_Pase S0013 C1 C2 S0097 Km_Pase S0013 C2 kcat_Pase S0013 C1 C2 S0099 Km_Pase S0013 C2 kcat_Pase S0013 S0100 Km_Pase S0013 C2 kcat_Pase S0013 C1 C2 S0101 Km_Pase S0013 C1 koff_GPVI_GPVI S0102 C1 koff_GPVI_GPVI S0103 C0 kon S0003 C1 C0 S0104 C1 koff_GPVI_GPVI S0102 C1 koff_GPVI_GPVI S0103 C1 koff_SH2 S0102 C1 koff_SH2 S0102 C1 2 koff_SH2 S0103 C1 koff_SH2 S0104 C2 kcat_TK S0012 C1 C2 S0102 Km_TK S0012 C1 kcat_TK S0009 S0102 Km_TK S0009 C1 2 kcat_TK S0009 S0103 Km_TK S0009 C1 kcat_TK S0009 S0104 Km_TK S0009 C1 koff_SH2 S0105 C1 kcat_TK S0095 S0105 Km_TK S0095 C1 kcat_TK S0097 S0105 Km_TK S0097 C1 kcat_TK S0099 S0105 Km_TK S0099 C2 kcat_TK S0100 C1 C2 S0105 Km_TK S0100 C1 kcat_TK S0102 S0105 Km_TK S0102 C1 2 kcat_TK S0103 S0105 Km_TK S0103 C1 kcat_TK S0104 S0105 Km_TK S0104 C2 kcat_Pase S0013 C1 C2 S0102 Km_Pase S0013 C2 2 kcat_Pase S0013 C1 C2 S0103 Km_Pase S0013 C2 kcat_Pase S0013 C1 C2 S0104 Km_Pase S0013 C1 Km_PLCg S0021 S0105 kcat_PLCg S0021 C1 Km_PLCg S0020 S0105 kcat_PLCg S0020 C1 Km_PLCg S0019 S0105 kcat_PLCg S0019 C1 koff_SH2 S0106 C2 kcat_Pase S0013 C1 C2 S0106 Km_Pase S0013 C1 Km_pPLCg S0021 S0106 kcat_pPLCg S0021 C1 Km_pPLCg S0020 S0106 kcat_pPLCg S0020 C1 Km_pPLCg S0019 S0106 kcat_pPLCg S0019 C1 kon S0101 C2 C1 S0107 C2 kcat_Pase S0013 S0107 Km_Pase S0013 C1 Km_pPLCg S0021 C2 C1 S0107 kcat_pPLCg S0021 C1 Km_pPLCg S0020 C2 C1 S0107 kcat_pPLCg S0020 C1 Km_pPLCg S0019 C2 C1 S0107 kcat_pPLCg S0019 G_IP3R IP3R_open psi_IM Ampere G_leak psi_PM