$\mathrm{cytosol}(\mathrm{Ins}+\mathrm{Ins1P}+\mathrm{Ins4P}+\mathrm{Ins14P2}+\mathrm{Ins145P3})+\mathrm{PM\_in}(2(\mathrm{PtdIns}+\mathrm{PtdIns4P}+\mathrm{PtdIns45P2}+\mathrm{PLC\_Gq\_GTP\_PtdIns}+\mathrm{PLC\_Gq\_GTP\_PtdIns4P}+\mathrm{PLC\_Gq\_GTP\_PtdIns45P2})+\mathrm{DG}+\mathrm{CDPDG}+\mathrm{PA})$ $\mathrm{cytosol}\mathrm{Ca\_cyt}+\mathrm{IM}(\mathrm{IP3Ri1}+2\mathrm{IP3Ri2}+\mathrm{IP3Ra}+2\mathrm{SERCA\_E1Ca2}+2\mathrm{SERCA\_E1PCa2}+2\mathrm{SERCA\_E2PCa2})+\mathrm{DTS}\mathrm{Ca\_dts}$ $\mathrm{IM}(\mathrm{IP3Rn}+\mathrm{IP3Ri1}+\mathrm{IP3Ro}+\mathrm{IP3Ra}+\mathrm{IP3Ri2}+\mathrm{IP3Rs})$ $\frac{\mathrm{IM}\mathrm{IP3Ro}}{\mathrm{IP3R\_total}}$ $\frac{\mathrm{IM}\mathrm{IP3Ra}}{\mathrm{IP3R\_total}}$ $(0.9\mathrm{pIP3Ra}+0.1\mathrm{pIP3Ro})(0.9\mathrm{pIP3Ra}+0.1\mathrm{pIP3Ro})(0.9\mathrm{pIP3Ra}+0.1\mathrm{pIP3Ro})(0.9\mathrm{pIP3Ra}+0.1\mathrm{pIP3Ro})$ $\frac{\mathrm{P\_o}\mathrm{IP3R\_total}}{4}$ $1.348E-2\ln \left(\frac{\mathrm{Ca\_dts}}{\mathrm{Ca\_cyt}}\right)$ $0.24996\mathrm{SERCA}$ $0.74989\mathrm{SERCA}$ $0.00014998\mathrm{SERCA}$ $\mathrm{IM}(\mathrm{SERCA\_E1}+\mathrm{SERCA\_E1Ca2}+\mathrm{SERCA\_E1PCa2}+\mathrm{SERCA\_E2PCa2}+\mathrm{SERCA\_E2P}+\mathrm{SERCA\_E2})$ $0.24996\mathrm{PMCA}$ $0.74989\mathrm{PMCA}$ $0.00014998\mathrm{PMCA}$ $\mathrm{PM\_in}(\mathrm{PMCA\_E1}+\mathrm{PMCA\_E1Ca2}+\mathrm{PMCA\_E1PCa2}+\mathrm{PMCA\_E2PCa2}+\mathrm{PMCA\_E2P}+\mathrm{PMCA\_E2})$ $1.348E-2\ln \left(\frac{\mathrm{Ca\_prp}}{\mathrm{Ca\_cyt}}\right)$ $\mathrm{PM\_in}(\mathrm{k1\_P2Y1}\mathrm{P2Y1}-\frac{\mathrm{k1\_P2Y1}}{\mathrm{Kact\_P2Y1}}\mathrm{P2Y1a})$ $\mathrm{PM\_in}(\mathrm{alpha\_P2Y1}\mathrm{k1\_P2Y1}\mathrm{P2Y1\_ADP}-\frac{\mathrm{k1\_P2Y1}}{\mathrm{Kact\_P2Y1}}\mathrm{P2Y1a\_ADP})$ $\mathrm{PM\_in}(\mathrm{beta\_P2Y1}\mathrm{k1\_P2Y1}\mathrm{P2Y1\_Gq\_GDP}-\frac{\mathrm{k1\_P2Y1}}{\mathrm{Kact\_P2Y1}}\mathrm{P2Y1a\_Gq\_GDP})$ $\mathrm{PM\_in}(\mathrm{alpha\_P2Y1}\mathrm{beta\_P2Y1}\mathrm{delta\_P2Y1}\mathrm{k1\_P2Y1}\mathrm{P2Y1\_ADP\_Gq\_GDP}-\frac{\mathrm{k1\_P2Y1}}{\mathrm{Kact\_P2Y1}}\mathrm{P2Y1a\_ADP\_Gq\_GDP})$ $\mathrm{cytosol}(\mathrm{eta\_P2Y1}\mathrm{k11\_P2Y1}\frac{\mathrm{PM\_in}}{\mathrm{cytosol}}\mathrm{P2Y1}\mathrm{Gq\_GDP}-\frac{\mathrm{eta\_P2Y1}\mathrm{k11\_P2Y1}}{\mathrm{Kg\_P2Y1}}\frac{\mathrm{PM\_in}}{\mathrm{cytosol}}\mathrm{P2Y1\_Gq\_GDP})$ $\mathrm{cytosol}(\mathrm{eta\_P2Y1}\mathrm{k11\_P2Y1}\frac{\mathrm{PM\_in}}{\mathrm{cytosol}}\mathrm{P2Y1\_ADP}\mathrm{Gq\_GDP}-\frac{\mathrm{eta\_P2Y1}\mathrm{k11\_P2Y1}}{\mathrm{gamma\_P2Y1}}\mathrm{Kg\_P2Y1}\frac{\mathrm{PM\_in}}{\mathrm{cytosol}}\mathrm{P2Y1\_ADP\_Gq\_GDP})$ $\mathrm{cytosol}(\mathrm{beta\_P2Y1}\mathrm{k11\_P2Y1}\frac{\mathrm{PM\_in}}{\mathrm{cytosol}}\mathrm{P2Y1a}\mathrm{Gq\_GDP}-\frac{\mathrm{k11\_P2Y1}}{\mathrm{Kg\_P2Y1}}\frac{\mathrm{PM\_in}}{\mathrm{cytosol}}\mathrm{P2Y1a\_Gq\_GDP})$ $\mathrm{cytosol}(\mathrm{beta\_P2Y1}\mathrm{k11\_P2Y1}\frac{\mathrm{PM\_in}}{\mathrm{cytosol}}\mathrm{P2Y1a\_ADP}\mathrm{Gq\_GDP}-\frac{\mathrm{k11\_P2Y1}}{\mathrm{delta\_P2Y1}\mathrm{gamma\_P2Y1}\mathrm{Kg\_P2Y1}}\frac{\mathrm{PM\_in}}{\mathrm{cytosol}}\mathrm{P2Y1a\_ADP\_Gq\_GDP})$ $\mathrm{PRP}(\mathrm{k3\_P2Y1}\frac{\mathrm{PM\_in}}{\mathrm{PRP}}\mathrm{P2Y1}\mathrm{ADP}-\mathrm{Kd\_P2Y1}\mathrm{k3\_P2Y1}\frac{\mathrm{PM\_in}}{\mathrm{PRP}}\mathrm{P2Y1\_ADP})$ $\mathrm{PRP}(\mathrm{k3\_P2Y1}\frac{\mathrm{PM\_in}}{\mathrm{PRP}}\mathrm{P2Y1\_Gq\_GDP}\mathrm{ADP}-\frac{\mathrm{Kd\_P2Y1}\mathrm{k3\_P2Y1}}{\mathrm{gamma\_P2Y1}}\frac{\mathrm{PM\_in}}{\mathrm{PRP}}\mathrm{P2Y1\_ADP\_Gq\_GDP})$ $\mathrm{PRP}(\mathrm{alpha\_P2Y1}\mathrm{k3\_P2Y1}\frac{\mathrm{PM\_in}}{\mathrm{PRP}}\mathrm{P2Y1a}\mathrm{ADP}-\mathrm{Kd\_P2Y1}\mathrm{k3\_P2Y1}\frac{\mathrm{PM\_in}}{\mathrm{PRP}}\mathrm{P2Y1a\_ADP})$ $\mathrm{PRP}(\mathrm{alpha\_P2Y1}\mathrm{k3\_P2Y1}\frac{\mathrm{PM\_in}}{\mathrm{PRP}}\mathrm{P2Y1a\_Gq\_GDP}\mathrm{ADP}-\frac{\mathrm{Kd\_P2Y1}\mathrm{k3\_P2Y1}}{\mathrm{delta\_P2Y1}\mathrm{gamma\_P2Y1}}\frac{\mathrm{PM\_in}}{\mathrm{PRP}}\mathrm{P2Y1a\_ADP\_Gq\_GDP})$ $\mathrm{PM\_in}(\mathrm{k\_GDP\_off\_P2Y1}\mathrm{P2Y1a\_Gq\_GDP}-\mathrm{k\_GDP\_on\_P2Y1}\mathrm{P2Y1a\_Gq}\mathrm{GDP})$ $\mathrm{PM\_in}(\mathrm{k\_GTP\_on\_P2Y1}\mathrm{P2Y1a\_Gq}\mathrm{GTP}-\mathrm{k\_GTP\_off\_P2Y1}\mathrm{P2Y1a\_Gq\_GTP})$ $\mathrm{PM\_in}(\mathrm{k\_GDP\_off\_P2Y1}\mathrm{P2Y1a\_ADP\_Gq\_GDP}-\mathrm{k\_GDP\_on\_P2Y1}\mathrm{P2Y1a\_ADP\_Gq}\mathrm{GDP})$ $\mathrm{PM\_in}(\mathrm{k\_GTP\_on\_P2Y1}\mathrm{P2Y1a\_ADP\_Gq}\mathrm{GTP}-\mathrm{k\_GTP\_off\_P2Y1}\mathrm{P2Y1a\_ADP\_Gq\_GTP})$ $\mathrm{cytosol}(\mathrm{k\_Gq\_GTP\_off\_P2Y1}\frac{\mathrm{PM\_in}}{\mathrm{cytosol}}\mathrm{P2Y1a\_Gq\_GTP}-\mathrm{k\_Gq\_GTP\_on\_P2Y1}\frac{\mathrm{PM\_in}}{\mathrm{cytosol}}\mathrm{P2Y1a}\mathrm{Gq\_GTP})$ $\mathrm{cytosol}(\mathrm{k\_Gq\_GTP\_off\_P2Y1}\frac{\mathrm{PM\_in}}{\mathrm{cytosol}}\mathrm{P2Y1a\_ADP\_Gq\_GTP}-\mathrm{k\_Gq\_GTP\_on\_P2Y1}\frac{\mathrm{PM\_in}}{\mathrm{cytosol}}\mathrm{P2Y1a\_ADP}\mathrm{Gq\_GTP})$ $\mathrm{cytosol}\mathrm{kGTP}\mathrm{Gq\_GTP}$ $\mathrm{cytosol}(\mathrm{kG\_on}\mathrm{Ga\_GTP}\mathrm{Gbg}-\mathrm{kG\_off}\mathrm{Gq\_GTP})$ $\mathrm{cytosol}(\mathrm{kG\_on}\mathrm{Ga\_GDP}\mathrm{Gbg}-\mathrm{kG\_off}\mathrm{Gq\_GDP})$ $\mathrm{cytosol}(\mathrm{k\_on\_RGS\_Gq\_GTP}\mathrm{PLC}\mathrm{Gq\_GTP}-\mathrm{k\_off\_RGS\_Gq\_GTP}\mathrm{PLC\_Gq\_GTP})$ $\mathrm{cytosol}\mathrm{k\_cat\_PLC}\mathrm{PLC\_Gq\_GTP}$ $\mathrm{cytosol}(\mathrm{k\_off\_RGS\_Gq\_GDP}\mathrm{PLC\_Gq\_GDP}-\mathrm{k\_on\_RGS\_Gq\_GDP}\mathrm{PLC}\mathrm{Gq\_GDP})$ $\mathrm{cytosol}(\mathrm{kon\_PLCbeta\_Gq\_GTP\_PtdIns}\mathrm{PLC\_Gq\_GTP}\frac{\mathrm{PM\_in}}{\mathrm{cytosol}}\mathrm{PtdIns}-\mathrm{koff\_PLCbeta\_Gq\_GTP\_PtdIns}\frac{\mathrm{PM\_in}}{\mathrm{cytosol}}\mathrm{PLC\_Gq\_GTP\_PtdIns})$ $\mathrm{PM\_in}\mathrm{kcat\_PLCbeta\_Gq\_GTP\_hydrolyzing\_PtdIns}\mathrm{PLC\_Gq\_GTP\_PtdIns}$ $\mathrm{cytosol}(\mathrm{kon\_PLCbeta\_Gq\_GTP\_PtdIns4P}\mathrm{PLC\_Gq\_GTP}\frac{\mathrm{PM\_in}}{\mathrm{cytosol}}\mathrm{PtdIns4P}-\mathrm{koff\_PLCbeta\_Gq\_GTP\_PtdIns4P}\frac{\mathrm{PM\_in}}{\mathrm{cytosol}}\mathrm{PLC\_Gq\_GTP\_PtdIns4P})$ $\mathrm{PM\_in}\mathrm{kcat\_PLCbeta\_Gq\_GTP\_hydrolyzing\_PtdIns4P}\mathrm{PLC\_Gq\_GTP\_PtdIns4P}$ $\mathrm{cytosol}(\mathrm{kon\_PLCbeta\_Gq\_GTP\_PtdIns45P2}\mathrm{PLC\_Gq\_GTP}\frac{\mathrm{PM\_in}}{\mathrm{cytosol}}\mathrm{PtdIns45P2}-\mathrm{koff\_PLCbeta\_Gq\_GTP\_PtdIns45P2}\frac{\mathrm{PM\_in}}{\mathrm{cytosol}}\mathrm{PLC\_Gq\_GTP\_PtdIns45P2})$ $\mathrm{PM\_in}\mathrm{kcat\_PLCbeta\_Gq\_GTP\_hydrolyzing\_PtdIns45P2}\mathrm{PLC\_Gq\_GTP\_PtdIns45P2}$ $\mathrm{PM\_in}\frac{\mathrm{kcat\_Phosphorylation\_of\_PtdIns}\mathrm{PtdIns4Kinase}\mathrm{PtdIns}}{\mathrm{Km\_Phosphorylation\_of\_PtdIns}+\mathrm{PtdIns}}$ $\mathrm{PM\_in}\frac{\mathrm{kcat\_Phosphorylation\_of\_PtdIns4P}\mathrm{PtdIns4P5Kinase}\mathrm{PtdIns4P}}{\mathrm{Km\_Phosphorylation\_of\_PtdIns4P}+\mathrm{PtdIns4P}}$ $\mathrm{PM\_in}\frac{\mathrm{kcat\_Dephosphorylation\_of\_PtdIns45P2}\mathrm{PtdIns45P2Phosphatase}\mathrm{PtdIns45P2}}{\mathrm{Km\_Dephosphorylation\_of\_PtdIns45P2}+\mathrm{PtdIns45P2}}$ $\mathrm{cytosol}\frac{\mathrm{kcat\_Dephosphorylation\_of\_Ins1P}\mathrm{InsPPhosphatase}\mathrm{Ins1P}}{\mathrm{Km\_Dephosphorylation\_of\_Ins1P}+\mathrm{Ins1P}}$ $\mathrm{cytosol}\frac{\mathrm{kcat\_Dephosphorylation\_of\_Ins4P}\mathrm{InsPPhosphatase}\mathrm{Ins4P}}{\mathrm{Km\_Dephosphorylation\_of\_Ins4P}+\mathrm{Ins4P}}$ $\mathrm{cytosol}\frac{\mathrm{kcat\_Dephosphorylation\_of\_Ins14P2}\mathrm{Ins14P21Phosphatase}\mathrm{Ins14P2}}{\mathrm{Km\_Dephosphorylation\_of\_Ins14P2}+\mathrm{Ins14P2}}$ $\mathrm{cytosol}\frac{\mathrm{kcat\_Dephosphorylation\_of\_Ins145P3}\mathrm{Ins145P35Phosphatase}\mathrm{Ins145P3}}{\mathrm{Km\_Dephosphorylation\_of\_Ins145P3}+\mathrm{Ins145P3}}$ $\mathrm{cytosol}\frac{\mathrm{kcat\_Phosphorylation\_of\_DG}\mathrm{DGKinase}\frac{\mathrm{PM\_in}}{\mathrm{cytosol}}\mathrm{DG}}{\mathrm{Km\_Phosphorylation\_of\_DG}+\frac{\mathrm{PM\_in}}{\mathrm{cytosol}}\mathrm{DG}}$ $\mathrm{PM\_in}\frac{\mathrm{kcat\_Synthesis\_of\_CDPDG}\mathrm{CDPDGSynthase}\mathrm{PA}\mathrm{CTP}}{\mathrm{Km\_PA\_Synthesis\_of\_CDPDG}\mathrm{Km\_CTP\_Synthesis\_of\_CDPDG}+\mathrm{Km\_PA\_Synthesis\_of\_CDPDG}\mathrm{CTP}+\mathrm{Km\_CTP\_Synthesis\_of\_CDPDG}\mathrm{PA}+\mathrm{PA}\mathrm{CTP}}$ $\mathrm{cytosol}\frac{\mathrm{kcat\_Synthesis\_of\_PtdIns}\frac{\mathrm{PM\_in}}{\mathrm{cytosol}}\mathrm{PtdInsSynthase}\frac{\mathrm{PM\_in}}{\mathrm{cytosol}}\mathrm{CDPDG}\mathrm{Ins}}{\mathrm{Km\_Ins\_Synthesis\_of\_PtdIns}\mathrm{Km\_CDPDG\_Synthesis\_of\_PtdIns}+\mathrm{Km\_Ins\_Synthesis\_of\_PtdIns}\frac{\mathrm{PM\_in}}{\mathrm{cytosol}}\mathrm{CDPDG}+\mathrm{Km\_CDPDG\_Synthesis\_of\_PtdIns}\mathrm{Ins}+\mathrm{Ins}\frac{\mathrm{PM\_in}}{\mathrm{cytosol}}\mathrm{CDPDG}}$ $\mathrm{cytosol}(\mathrm{kf\_Activation\_of\_PKC}\mathrm{PKC}-\mathrm{kb\_Activation\_of\_PKC}\mathrm{PKCa})$ $\mathrm{cytosol}(\mathrm{kf\_Activation\_of\_PKC\_Ca\_cyt}\mathrm{PKC\_Ca\_cyt}-\mathrm{kb\_Activation\_of\_PKC\_Ca\_cyt}\mathrm{PKCa\_Ca\_cyt})$ $\mathrm{cytosol}(\mathrm{kf\_Activation\_of\_PKC\_Ca\_cyt\_DG}\mathrm{PKC\_Ca\_cyt\_DG}-\mathrm{kb\_Activation\_of\_PKC\_Ca\_cyt\_DG}\mathrm{PKCa\_Ca\_cyt\_DG})$ $\mathrm{cytosol}(\mathrm{kon\_PKC\_Ca\_cyt}\mathrm{PKC}\mathrm{Ca\_cyt}-\mathrm{koff\_PKC\_Ca\_cyt}\mathrm{PKC\_Ca\_cyt})$ $\mathrm{cytosol}(\mathrm{kon\_PKC\_Ca\_cyt\_DG}\mathrm{PKC\_Ca\_cyt}\frac{\mathrm{PM\_in}}{\mathrm{cytosol}}\mathrm{DG}-\mathrm{koff\_PKC\_Ca\_cyt\_DG}\mathrm{PKC\_Ca\_cyt\_DG})$ $\mathrm{cytosol}(\mathrm{kon\_PKC\_Ca\_cyt}\mathrm{PKCa}\mathrm{Ca\_cyt}-\mathrm{koff\_PKC\_Ca\_cyt}\mathrm{PKCa\_Ca\_cyt})$ $\mathrm{cytosol}(\mathrm{kon\_PKC\_Ca\_cyt\_DG}\mathrm{PKCa\_Ca\_cyt}\frac{\mathrm{PM\_in}}{\mathrm{cytosol}}\mathrm{DG}-\mathrm{koff\_PKC\_Ca\_cyt\_DG}\mathrm{PKCa\_Ca\_cyt\_DG})$ $\mathrm{cytosol}\frac{\mathrm{kcat\_PKCa\_phosphorylating\_PLC}\mathrm{PKCa\_Ca\_cyt\_DG}\mathrm{PLC}}{\mathrm{Km\_PKCa\_phosphorylating\_PLC}+\mathrm{PLC}}$ $\mathrm{cytosol}\frac{\mathrm{Vmax\_Dephosphorylation\_of\_pPLC}\mathrm{pPLC}}{\mathrm{Km\_Dephosphorylation\_of\_pPLC}+\mathrm{pPLC}}$ $\mathrm{G\_IP3R}\mathrm{IP3R\_open}\mathrm{psi\_IM}\mathrm{Ampere}$ $\mathrm{cytosol}\mathrm{k\_SERCA\_2f}\mathrm{SERCA\_E1}\mathrm{Ca\_cyt}\mathrm{Ca\_cyt}$ $\mathrm{IM}\mathrm{k\_SERCA\_2r}\mathrm{SERCA\_E1Ca2}$ $\mathrm{IM}\mathrm{k\_SERCA\_3f}\mathrm{SERCA\_E1Ca2}$ $\mathrm{IM}\mathrm{k\_SERCA\_3r}\mathrm{SERCA\_E1PCa2}$ $\mathrm{IM}\mathrm{k\_SERCA\_4f}\mathrm{SERCA\_E1PCa2}$ $\mathrm{IM}\mathrm{k\_SERCA\_4r}\mathrm{SERCA\_E2PCa2}$ $\mathrm{IM}\mathrm{k\_SERCA\_5f}\mathrm{SERCA\_E2PCa2}$ $\mathrm{DTS}\mathrm{k\_SERCA\_5r}\mathrm{SERCA\_E2P}\mathrm{Ca\_dts}\mathrm{Ca\_dts}$ $\mathrm{cytosol}\frac{\mathrm{IM}}{\mathrm{cytosol}}\mathrm{IP3Rn}\frac{(\mathrm{k\_IP3R\_k1}\mathrm{k\_IP3R\_L1}+\mathrm{k\_IP3R\_l2})\mathrm{Ca\_cyt}}{\mathrm{k\_IP3R\_L1}+\mathrm{Ca\_cyt}(1+\frac{\mathrm{k\_IP3R\_L1}}{\mathrm{k\_IP3R\_L3}})}$ $\mathrm{IM}\mathrm{IP3Ri1}(\mathrm{k\_IP3R\_k1b}+\mathrm{k\_IP3R\_l2b})$ $\mathrm{cytosol}\frac{\mathrm{IM}}{\mathrm{cytosol}}\mathrm{IP3Rn}\mathrm{Ins145P3}\frac{\mathrm{k\_IP3R\_k2}\mathrm{k\_IP3R\_L3}+\mathrm{k\_IP3R\_l4}\mathrm{Ca\_cyt}}{\mathrm{k\_IP3R\_L3}+\mathrm{Ca\_cyt}(1+\frac{\mathrm{k\_IP3R\_L3}}{\mathrm{k\_IP3R\_L1}})}$ $\mathrm{cytosol}\frac{\mathrm{IM}}{\mathrm{cytosol}}\mathrm{IP3Ro}\frac{\mathrm{k\_IP3R\_k2b}+\mathrm{k\_IP3R\_l4b}\mathrm{Ca\_cyt}}{1+\frac{\mathrm{Ca\_cyt}}{\mathrm{k\_IP3R\_L5}}}$ $\mathrm{cytosol}\frac{\mathrm{IM}}{\mathrm{cytosol}}\mathrm{IP3Ro}\frac{(\mathrm{k\_IP3R\_k4}\mathrm{k\_IP3R\_L5}+\mathrm{k\_IP3R\_l6})\mathrm{Ca\_cyt}}{\mathrm{k\_IP3R\_L5}+\mathrm{Ca\_cyt}}$ $\mathrm{cytosol}\frac{\mathrm{IM}}{\mathrm{cytosol}}\mathrm{IP3Ra}\frac{\mathrm{k\_IP3R\_L1}(\mathrm{k\_IP3R\_k4b}+\mathrm{k\_IP3R\_l6b})}{\mathrm{k\_IP3R\_L1}+\mathrm{Ca\_cyt}}$ $\mathrm{cytosol}\frac{\frac{\mathrm{IM}}{\mathrm{cytosol}}\mathrm{IP3Ra}(\mathrm{k\_IP3R\_k1}\mathrm{k\_IP3R\_L1}+\mathrm{k\_IP3R\_l2})\mathrm{Ca\_cyt}}{\mathrm{k\_IP3R\_L1}+\mathrm{Ca\_cyt}}$ $\mathrm{IM}\mathrm{IP3Ri2}(\mathrm{k\_IP3R\_k1b}+\mathrm{k\_IP3R\_l2b})$ $\mathrm{cytosol}\frac{\mathrm{IM}}{\mathrm{cytosol}}\mathrm{IP3Ro}\frac{\mathrm{k\_IP3R\_k3}\mathrm{k\_IP3R\_L5}}{\mathrm{k\_IP3R\_L5}+\mathrm{Ca\_cyt}}$ $\mathrm{IM}\mathrm{IP3Rs}\mathrm{k\_IP3R\_k3b}$ $\mathrm{G\_leak}\mathrm{PM\_in}\mathrm{psi\_PM\_in}$ $\mathrm{cytosol}\mathrm{k\_PMCA\_2f}\mathrm{PMCA\_E1}\mathrm{Ca\_cyt}\mathrm{Ca\_cyt}$ $\mathrm{PM\_in}\mathrm{k\_PMCA\_2r}\mathrm{PMCA\_E1Ca2}$ $\mathrm{PM\_in}\mathrm{k\_PMCA\_3f}\mathrm{PMCA\_E1Ca2}$ $\mathrm{PM\_in}\mathrm{k\_PMCA\_3r}\mathrm{PMCA\_E1PCa2}$ $\mathrm{PM\_in}\mathrm{k\_PMCA\_4f}\mathrm{PMCA\_E1PCa2}$ $\mathrm{PM\_in}\mathrm{k\_PMCA\_4r}\mathrm{PMCA\_E2PCa2}$ $\mathrm{PM\_in}\mathrm{k\_PMCA\_5f}\mathrm{PMCA\_E2PCa2}$ $\mathrm{PRP}\mathrm{k\_PMCA\_5r}\mathrm{PMCA\_E2P}\mathrm{Ca\_prp}\mathrm{Ca\_prp}$