My long-term research goal is to understand how cells convert molecular information into emergent decisions. I am interested especially in irreversible processes such as apoptosis, senescence, and differentiation. When do cells commit to a particular fate? What are the molecular factors that mediate this decision? Can these decisions be altered through rational perturbations? My future lab will investigate the timing and mechanism of irreversible processes in human cells using a variety of experimental and computational approaches including gene expression profiling, time-lapse microscopy, single molecular mRNA detection, high-content image analysis, computational modeling, and statistical learning. Our ultimate goal will be to not only understand how cellular information is processed under physiological conditions, but to discover how it can be manipulated to achieve favorable outcomes in a disease context.
You can read a more detailed description of my research interests
are the wonderful labs where I've spent time:
Lahav Lab | DNA damage and cell signaling at HMS
Diamond Lab | blood biology and drug discovery at UPenn
Lab | multiscale modeling lab at UPenn
Brass Lab | platelet signaling lab at UPenn
Ingram Lab | metabolic engineering lab at UF